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Related Experiment Video

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In Vitro Thrombosis Test for Ventricular Assist Devices

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In vitro testing of a funnel-tip catheter with different clot types to decrease clot migration in mechanical

Emily S Payne¹, Samantha Krost-Reuhl¹, Axel Heimann²

¹Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences

|September 1, 2022

Summary

This summary is machine-generated.

A new funnel-shaped tip significantly improves mechanical thrombectomy for acute ischemic stroke, achieving higher first-pass recanalization rates and reducing clot disruption. This innovation enhances treatment efficacy for large vessel occlusion stroke.

Keywords:

Ischemic stroke blood coagulation catheters embolectomy

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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

Area of Science:

Neurology
Medical Devices
Interventional Cardiology

Background:

Mechanical thrombectomy is a standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO).
Embolism in new territories occurs in 8.6% of cases, potentially due to clot abruption or collateral flow.
A novel funnel-shaped tip catheter was developed to improve first-pass recanalization and safety.

Purpose of the Study:

To compare the efficacy of a funnel-shaped tip catheter versus a standard tip catheter in mechanical thrombectomy.
To evaluate the impact of different clot compositions and aging times on recanalization rates.

Main Methods:

An in vitro study involving 80 mechanical thrombectomy procedures per tip type.
Utilized two stent retrievers (Trevo XP ProVue 3/20mm, 4/20mm) and four clot types (hard/soft, 0-24h/72h aged).

Main Results:

The funnel-shaped tip achieved significantly higher first-pass recanalization rates (mTICI 3) at 70.0% compared to the standard tip at 30.0% (P < .001).
This improvement was consistent across various clot types and stent retrievers.
Harder and younger clots (0-24h) demonstrated higher recanalization rates compared to softer and older (72h) clots.

Conclusions:

The funnel-shaped tip significantly enhances first-pass recanalization rates in mechanical thrombectomy for AIS.
This design also reduces the incidence of clot abruption during stent retrieval.
Clot characteristics, including composition and age, influence thrombectomy outcomes.