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Updated: Aug 30, 2025

The use of Biofeedback in Clinical Virtual Reality: The INTREPID Project
Published on: November 12, 2009
Prospective randomized controlled trial to evaluate effectiveness of virtual reality to decrease anxiety in
Chinnakhet Ketsuwan1, Wijittra Matang1, Wattanachai Ratanapornsompong1
1Division of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Immersive virtual reality (VR) significantly reduced anxiety and improved patient satisfaction during flexible cystoscopy. This technology enhanced willingness to repeat the procedure, offering a promising non-pharmacological intervention.
Area of Science:
- Urology
- Medical Technology
- Pain Management
Background:
- Flexible cystoscopy is an invasive procedure often associated with patient anxiety and discomfort.
- Minimizing patient distress during cystoscopy is crucial for improving procedural outcomes and patient experience.
Purpose of the Study:
- To assess the efficacy of immersive virtual reality (VR) as a distraction technique for reducing anxiety and pain during flexible cystoscopy.
- To evaluate the impact of VR on patient satisfaction and willingness to undergo the procedure again.
Main Methods:
- A prospective study involving 270 patients undergoing flexible cystoscopy, randomly assigned to either a VR group or a control group.
- Anxiety levels were measured using the State-Trait Anxiety Inventory, while pain, satisfaction, and willingness to repeat were assessed via visual analog scales.
- Hemodynamic parameters including systolic and diastolic blood pressure and heart rate were monitored in both groups.
Main Results:
- The VR group exhibited significantly lower anxiety levels (p=0.001) and improved satisfaction and willingness to repeat the procedure compared to the control group.
- A significant reduction in systolic pressure, diastolic pressure, and heart rate was observed in the VR group (p=0.001).
- No significant differences were found in pain intensity or oxygen saturation between the groups.
Conclusions:
- Immersive virtual reality is an effective tool for mitigating anxiety during flexible cystoscopy.
- VR technology enhances patient satisfaction and willingness to undergo repeat procedures, presenting a valuable non-pharmacological approach.
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