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Updated: Aug 30, 2025

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Anti-inflammatory agents as modulators of the inflammation in adipose tissue: A systematic review

Sara Sayonara da Cruz Nascimento1, Jaluza Luana Carvalho de Queiroz2, Amanda Fernandes de Medeiros2

  • 1Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Plos One
|September 1, 2022
PubMed

Insights

This review details how anti-inflammatory agents combat obesity by reducing inflammation in adipose tissue. It identifies key mechanisms and compounds for future therapeutic targets in obesity treatment.

Area of Science:

  • Pharmacology
  • Immunology
  • Metabolism

Background:

  • Obesity is linked to increased inflammation and adipose tissue expansion, posing health risks.
  • Current anti-inflammatory treatments for obesity lack efficacy, necessitating research into novel therapeutic targets.
  • Understanding the mechanisms of anti-inflammatory agents in adipose tissue is crucial for developing effective obesity interventions.

Purpose of the Study:

  • To systematically review and describe the mechanisms of action of various anti-inflammatory agents within adipose tissue.
  • To identify and analyze compounds (drugs, natural, and synthetic) with anti-inflammatory properties relevant to obesity.
  • To elucidate the molecular pathways targeted by these agents in adipose tissue.

Main Methods:

  • Systematic review registered in PROSPERO (CRD42020182897).
  • Article selection based on PICOS criteria across major scientific databases (PubMed, Scopus, etc.).
  • Methodological quality assessed using SYRCLE, with 41 eligible articles selected from 1511 initial records.

Main Results:

  • Identified 41 eligible studies detailing 8 drugs, 28 natural compounds, and 5 synthetic compounds with anti-inflammatory effects.
  • Demonstrated that these agents reduce inflammatory cytokine expression via metabolic pathways.
  • Observed decreased macrophage infiltration in adipose tissue and promoted M1 to M2 macrophage polarization.

Conclusions:

  • Anti-inflammatory agents modulate key metabolic pathways in adipose tissue to reduce inflammation.
  • These agents offer promising therapeutic targets for obesity by influencing macrophage behavior and cytokine production.
  • Further research into these pathways can lead to more effective obesity treatments.

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