Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluoride-induced chronic renal failure.

O Lantz, M H Jouvin, M C De Vernejoul

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |August 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Circulating tumor DNA changes for early monitoring of anti-PD1 immunotherapy: a proof-of-concept study.

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Pre-transplant donor CD4<sup>-</sup> invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease.

    Leukemia·2016
    Same author

    Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases.

    Clinical and experimental immunology·2014
    Same author

    The use of different dual X-ray absorptiometry brands in a multicenter clinical trial: consequences and limits.

    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2013
    Same author

    Kinetic Quantitative PCR vs End-Point Quantitative PCR with Internal Standard.

    Methods in molecular medicine·2011
    Same author

    Quantifying amplicons with ELISA.

    Methods in molecular medicine·2011
    Same journal

    Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    High Protein Diets: What to Tell Our Patients.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    Same journal

    Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
    See all related articles

    Chronic high fluoride intake from mineral water caused severe kidney damage and bone disease in a young patient. This case highlights the risks of excessive fluoride consumption, even from seemingly natural sources.

    Area of Science:

    • Nephrology
    • Toxicology
    • Endocrinology

    Background:

    • Renal fluoride toxicity in humans is not well-documented, despite experimental evidence of kidney damage from methoxyflurane.
    • Chronic renal insufficiency linked to long-term fluoride exposure is rarely observed in clinical settings.

    Observation:

    • A case of fluoride intoxication was reported in a patient with potomania, who consumed Vichy water with a high fluoride concentration (8.5 mg/L).
    • The patient presented with prominent features of fluoride osteosclerosis and end-stage renal failure.

    Findings:

    • The patient's young age, prolonged excessive fluoride intake, and lack of other contributing factors strongly suggest a causal link between fluoride intoxication and renal failure.
    • This case provides rare clinical evidence of severe renal damage resulting from chronic fluoride overexposure.

    Related Experiment Videos

    Implications:

    • This case underscores the potential nephrotoxic effects of chronic high fluoride intake, even from mineral water sources.
    • It highlights the importance of monitoring fluoride levels in patients with unexplained renal failure, particularly those with high consumption of fluoridated beverages.
    • Further research is warranted to establish definitive diagnostic criteria and understand the long-term renal consequences of chronic fluoride exposure.