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Pharmacologic Therapies for Non-Muscle Invasive Bladder Cancer: Current and Future Treatments.
Ilana P Goldberg1, Benjamin Lichtbroun2, Eric A Singer2
1Tufts University School of Medicine, Boston, MA, USA.
Archives of Pharmacology and Therapeutics
|September 2, 2022
Summary
Novel therapies are emerging for non-muscle invasive bladder cancer (NMIBC) due to Bacille Calmette-Guerin (BCG) shortages and unresponsiveness. This review explores new treatments, including checkpoint inhibitors and innovative drug delivery systems, to improve patient outcomes.
Area of Science:
- Uro-oncology
- Cancer Therapeutics
Background:
- Non-muscle invasive bladder cancer (NMIBC) is a common malignancy with a significant risk of progression.
- Current treatments like intravesical Bacille Calmette-Guerin (BCG) face challenges including shortages and unresponsiveness.
Purpose of the Study:
- To review the evolving landscape of therapeutic options for NMIBC.
- To highlight novel agents and drug delivery systems for NMIBC management.
Main Methods:
- Narrative review of current and emerging NMIBC treatments.
- Discussion of systemic therapies, oncolytic viruses, and novel drug delivery devices.
Main Results:
- Pembrolizumab is the first FDA-approved systemic therapy for BCG-unresponsive NMIBC.
- Investigational agents include checkpoint inhibitors, adenovirus-based therapies (CG0070, rAd-IFNa/Syn3), and new delivery systems (GemRIS, hyperthermia).
Conclusions:
- Emerging therapies offer promising alternatives for NMIBC, addressing limitations of current treatments.
- The management of NMIBC is expected to evolve with advancements in therapeutic options and drug delivery.
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