Osteosarcoma mineralization changes on radiographs have moderate correlation to chemotherapy response using bone...

Area of Science:

• Oncology
• Radiology
• Medical Imaging

Background:

• Osteosarcoma patient survival is linked to chemotherapy response.
• Radiographic mineralization changes are hypothesized to reflect chemotherapy response but lack modern analysis.

Purpose of the Study:

• To analyze radiographic mineralization changes in osteosarcoma patients.
• To determine if these changes correlate with chemotherapy response.

Main Methods:

• Retrospective review of 31 high-grade, conventional osteosarcoma patient radiographs before and after neoadjuvant chemotherapy.
• Co-registration of pre- and post-chemotherapy images.
• Normalized tumor luminance measurements to assess relative mineralization changes.

Main Results:

• Normalized osteosarcoma mineralization change showed a moderate, statistically significant correlation (ρ = 0.36, P = 0.038) with tumor necrosis.
• A moderate, positive correlation was observed between mineralization changes and chemotherapy response.

Conclusions:

• Osteosarcoma mineralization changes during chemotherapy exhibit a moderate positive correlation with treatment response.
• Further prospective studies with standardized imaging techniques are needed to confirm prognostic value.