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SARS-CoV-2 Effects on the Male Genitourinary System

Zachary M Connelly1, Dustin Whitaker2, Alexandra Dullea3

  • 1Department of Surgery, Louisiana State University Health Shreveport Shreveport, LA, USA.

American Journal of Clinical and Experimental Urology
|September 2, 2022
PubMed

Insights

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) impacts the male genitourinary system, causing issues like urinary problems and persistent virus presence. Transmission via semen is unlikely, but long-term effects require further study.

Area of Science:

  • Urology
  • Virology
  • Infectious Diseases

Background:

  • Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) emerged in 2019, significantly impacting global health.
  • Research is expanding beyond pulmonary effects to investigate SARS-CoV-2's broader systemic impact.
  • The male genitourinary system's response to SARS-CoV-2 warrants comprehensive review.

Purpose of the Study:

  • To review current literature on SARS-CoV-2's effects on the male genitourinary system.
  • To assess the potential for SARS-CoV-2 transmission through semen.
  • To identify viral reservoirs and clinical manifestations within the male genitourinary tract.

Main Methods:

  • Systematic literature review of studies on SARS-CoV-2 and the male genitourinary system.
  • Analysis of data concerning viral presence in semen and genitourinary tissues.
  • Evaluation of reported clinical outcomes, including voiding dysfunction and penile complications.

Main Results:

  • Evidence suggests SARS-CoV-2 is unlikely to be transmitted via semen, contrary to initial concerns.
  • Studies indicate SARS-CoV-2 can reside in the male genitourinary tract, with potential for viral persistence.
  • Reported genitourinary complications include increased voiding problems and rare penile issues post-infection.

Conclusions:

  • While semen transmission is improbable, SARS-CoV-2 can affect the male genitourinary system.
  • Viral persistence in the genitourinary tract post-infection is a noted concern.
  • Further long-term studies are essential to fully understand SARS-CoV-2's lasting impact on male urogenital health.
Keywords:
SARS-CoV-2bladdermale reproductionprostatetestes

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