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The DST and posttraumatic stress disorder.

H Kudler, J Davidson, K Meador

    The American Journal of Psychiatry
    |August 1, 1987
    PubMed
    Summary
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    Cortisol nonsuppression is uncommon in male combat veterans with posttraumatic stress disorder (PTSD). However, rates increase significantly when major depressive disorder is also present.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Trauma Studies

    Background:

    • Posttraumatic stress disorder (PTSD) is a complex mental health condition often associated with neuroendocrine dysregulation.
    • The dexamethasone suppression test (DST) is a tool used to assess hypothalamic-pituitary-adrenal (HPA) axis function, which is implicated in stress responses.

    Purpose of the Study:

    • To investigate the prevalence of cortisol nonsuppression in male combat veterans diagnosed with PTSD.
    • To examine the relationship between cortisol nonsuppression and the presence of comorbid major depressive disorder (MDD) in this population.

    Main Methods:

    • The dexamethasone suppression test (DST) was administered to a cohort of 28 male combat veterans with PTSD.
    • Participants were assessed for the presence of major depressive disorder using the Research Diagnostic Criteria.

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    Main Results:

    • Overall, 21% (6 out of 28) of the veterans exhibited cortisol nonsuppression.
    • The rate of nonsuppression was markedly higher (50%) in veterans with comorbid major depressive disorder compared to those without (6%).

    Conclusions:

    • Cortisol nonsuppression is a relatively rare finding in male combat veterans with PTSD.
    • The presence of major depressive disorder significantly increases the likelihood of cortisol nonsuppression in individuals with PTSD.