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Bisphenols induce human genomic damage and modulate HERVs/env expression.

Stefano Ruberto1, Alfredo Santovito2, Elena R Simula1

  • 1Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Sassari, Italy.

Environmental and Molecular Mutagenesis
|September 2, 2022
PubMed
Summary

Bisphenol A (BPA) and its analogs, bisphenol F (BPF) and bisphenol S (BPS), show genotoxic effects on human blood cells. Exposure to these chemicals also impacts human endogenous retroviruses (HERVs) expression.

Keywords:
BPABPFBPSHERVsgenotoxicologymicronucleus

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Area of Science:

  • Environmental Health
  • Toxicology
  • Molecular Biology

Background:

  • Bisphenol A (BPA) is an endocrine-disrupting chemical used in plastics.
  • Concerns over BPA's health effects have led to increased use of BPA analogs like BPF and BPS.
  • Regulatory status of BPF and BPS remains unclear, necessitating further research.

Purpose of the Study:

  • To investigate the genotoxicity of BPA, BPF, and BPS on human peripheral blood mononuclear cells.
  • To examine the impact of BPA, BPF, and BPS exposure on human endogenous retroviruses (HERVs) expression.

Main Methods:

  • In vitro micronucleus assay was used to assess genotoxicity.
  • Human peripheral blood mononuclear cells were exposed to varying concentrations of BPA, BPF, and BPS.
  • HERVs expression levels were analyzed following bisphenol exposure.

Main Results:

  • BPA and BPF demonstrated significant genotoxic effects at tested concentrations.
  • BPS also showed genotoxicity at specific concentrations.
  • BPA exposure upregulated HERVs expression, while BPF and BPS downregulated it.

Conclusions:

  • BPA and its analogs (BPF, BPS) exhibit toxic effects on human blood cells.
  • These bisphenols can modulate the expression of human endogenous retroviruses (HERVs).
  • Further investigation into the health implications of BPA analogs is warranted.