Related Experiment Video
Updated: Aug 30, 2025
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future
Dilara Akhoundova1, Mark A Rubin2
1Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland; Department of Medical Oncology, Inselspital, University Hospital of Bern, 3010 Bern, Switzerland.
Abstract:
Next-generation DNA sequencing technology has dramatically advanced clinical oncology through the identification of therapeutic targets and molecular biomarkers, leading to the personalization of cancer treatment with significantly improved outcomes for many common and rare tumor entities. More recent developments in advanced tumor profiling now enable dissection of tumor molecular architecture and the functional phenotype at cellular and subcellular resolution. Clinical translation of high-resolution tumor profiling and integration of multi-omics data into precision treatment, however, pose significant challenges at the level of prospective validation and clinical implementation. In this review, we summarize the latest advances in multi-omics tumor profiling, focusing on spatial genomics and chromatin organization, spatial transcriptomics and proteomics, liquid biopsy, and ex vivo modeling of drug response. We analyze the current stages of translational validation of these technologies and discuss future perspectives for their integration into precision treatment.
Insights
Advanced tumor profiling using multi-omics data enhances precision cancer treatment. This review covers spatial genomics, transcriptomics, proteomics, liquid biopsies, and drug response modeling for clinical integration.
Area of Science:
- Oncology
- Genomics
- Proteomics
- Biotechnology
Background:
- Next-generation sequencing (NGS) has revolutionized clinical oncology by identifying therapeutic targets and biomarkers.
- This has enabled personalized cancer treatment, improving outcomes for various tumor types.
- Advanced tumor profiling now allows detailed analysis of molecular architecture and cellular function.
Purpose of the Study:
- To review recent advancements in multi-omics tumor profiling technologies.
- To analyze the translational validation and clinical implementation challenges of these technologies.
- To discuss future perspectives for integrating high-resolution tumor profiling into precision medicine.
Main Methods:
- Review of spatial genomics and chromatin organization techniques.
- Summary of spatial transcriptomics and proteomics methodologies.
- Analysis of liquid biopsy and ex vivo drug response modeling approaches.
Main Results:
- Multi-omics profiling offers high-resolution insights into tumor molecular and functional phenotypes.
- Technologies like spatial genomics and liquid biopsies are advancing rapidly.
- Significant challenges remain in prospective validation and clinical integration.
Conclusions:
- High-resolution multi-omics tumor profiling holds immense promise for precision oncology.
- Overcoming translational and implementation hurdles is crucial for clinical adoption.
- Future integration of these advanced technologies will further personalize cancer care.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...