Effect of Microporous Polysaccharide Particles in Patients Undergoing Mastectomy

Area of Science:

• Surgical Innovation
• Biomaterials in Medicine
• Post-Mastectomy Care

Background:

• Microporous polysaccharide particles (MPP) are used to enhance surgical hemostasis.
• The impact of MPP on short-term complications following mastectomy requires further investigation.

Purpose of the Study:

• To evaluate the effect of MPP on short-term complications after mastectomy.
• To identify patient factors associated with MPP use and post-operative outcomes.

Main Methods:

• Retrospective chart review of 190 patients undergoing unilateral mastectomy without reconstruction.
• Primary endpoints included antibiotic use, drainage, readmission, wound dehiscence, and drain removal time.
• Statistical analysis using Wilcoxon rank sum, Student t, Chi-square, and Fisher exact tests.

Main Results:

• No significant difference in complications (antibiotic prescription, drainage, readmission, dehiscence) between MPP and non-MPP groups.
• MPP patients were older and had lower albumin levels.
• Higher BMI, diabetes, and lymphovenous anastomosis (LVA) were associated with increased drainage; LVA patients were less likely to receive MPP.

Conclusions:

• MPP did not alter short-term post-mastectomy complication rates in this cohort.
• Consider MPP for patients at higher risk of seroma, particularly those undergoing axillary surgery with LVA.