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Can C-reactive protein predict coagulation in off pump coronary artery bypass grafting? A cohort study
Xiaojie Liu1,2, Yang Yu2, Lijuan Wang2
1Department of Anestheiology, the Affiliated Hospital of Qingdao University, No. 59, Haier Road, Qingdao, Shandong province, China.
Insights
Preoperative C-reactive protein (CRP) levels predict reduced postoperative bleeding in off-pump coronary artery bypass grafting (CABG) patients. This finding suggests CRP may serve as a novel marker for bleeding risk in cardiovascular surgery.
Area of Science:
- Cardiovascular Surgery
- Biomarkers
- Inflammation
Background:
- Previous research indicated C-reactive protein (CRP) predicts bleeding post-on-pump CABG.
- The role of CRP in predicting bleeding after off-pump CABG remains unevaluated.
Purpose of the Study:
- To determine if preoperative C-reactive protein (CRP) is a novel marker for postoperative bleeding in patients undergoing off-pump coronary artery bypass grafting (CABG).
Main Methods:
- Retrospective cohort study involving 537 patients undergoing off-pump isolated primary CABG.
- Analysis of preoperative data, including CRP levels, correlated with postoperative bleeding volume within 24 hours.
- Multivariable regression analyses were performed to identify independent predictors.
Main Results:
- Higher preoperative C-reactive protein (CRP) concentration was significantly associated with lower postoperative bleeding volume (B = -0.089, P < 0.05).
- Fibrinogen levels also showed a correlation with bleeding volume (B = 0.594, p < 0.001).
Conclusions:
- Preoperative CRP concentration is an independent predictor of postoperative bleeding volume within 24 hours after off-pump CABG.
- CRP shows potential as a novel coagulation index for patients with coronary artery atherosclerotic disease.
Background:
Previous study found that C-reactive protein (CRP) can predict bleeding after on-pump CABG. To evaluate whether preoperative C-reactive protein (CRP) can be a novel marker of postoperative bleeding in patients having off-pump coronary artery bypass grafting (CABG).
Methods:
This is a retrospective cohort study. Multiple variable regression analyses were performed. 537 patients undergoing off-pump isolated primary CABG at Fuwai Hospital from September 2017 to July 2018 were recorded. The primary endpoint was bleeding volume within 24 h after surgery.
Results:
Data of 537 patients undergoing off-pump isolated primary CABG at Fuwai Hospital were recorded. The correlations between bleeding volume within 24 h after surgery and preoperative data were analyzed with univariate and multivariate linear regression. Much more preoperative CRP concentration (B = -0.089, P < 0.05) was associated with less postoperative bleeding volume and fibrinogen (B = 0.594, p < 0.001).
Conclusions:
Preoperative CRP concentration is independently correlated with the postoperative volume of bleeding within 24 h. CRP may become a novel coagulation index in coronary artery atherosclerotic disease.
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