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Testosterone and Covid-19: An update.

Aksam Yassin1,2, Ridwan Shabsigh3,4, Raed M Al-Zoubi1,5

  • 1Surgical Research Section, Hamad Medical Corporation, Doha, Qatar.

Reviews in Medical Virology
|September 3, 2022
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Summary
This summary is machine-generated.

Men face higher risks for severe Covid-19. This review explores testosterone's unclear role in SARS-CoV-2 infection and Covid-19 severity, examining its potential as a biomarker and therapeutic agent.

Keywords:
prostatesexual medicinetestosterone

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Public Health

Background:

  • Male gender is associated with increased risk and severity of Covid-19.
  • The specific role of testosterone (T) in SARS-CoV-2 infection and Covid-19 outcomes is not fully understood.
  • Existing research suggests both protective and detrimental effects of testosterone.

Purpose of the Study:

  • To review epidemiological and biological evidence on testosterone's role in SARS-CoV-2 infection.
  • To investigate testosterone's influence on Covid-19 severity.
  • To discuss testosterone as a potential biomarker and therapeutic strategy for Covid-19.

Main Methods:

  • Systematic review of current epidemiological data.
  • Analysis of biological mechanisms linking testosterone to viral infection and immune response.
  • Literature synthesis of studies investigating testosterone levels in Covid-19 patients.

Main Results:

  • Evidence suggests male sex is a risk factor for severe Covid-19.
  • Testosterone's impact on Covid-19 is complex, with potential dual roles.
  • Further research is needed to clarify testosterone's precise effects.

Conclusions:

  • Testosterone's role in Covid-19 pathogenesis and severity requires further elucidation.
  • Testosterone may hold potential as a biomarker for risk stratification in Covid-19.
  • Testosterone supplementation could be explored as a future therapeutic or preventative approach for Covid-19.