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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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[Radiation therapy and targeted therapies: Risks and opportunities].

E Nicolas1, F Lucia2

  • 1Département de radiothérapie et oncologie, hôpital Pitié-Salpêtrière Charles-Foix, APHP, 47-83, boulevard de l'Hôpital, 75013 Paris, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|September 3, 2022
PubMed
Summary
This summary is machine-generated.

Combining radiotherapy with targeted therapies shows synergistic effects in cancer treatment. Further research is needed to centralize toxicity and efficacy data for these promising cancer treatment strategies.

Keywords:
AssociationCombined modality therapyMolecular targeted therapyRadiotherapyRadiothérapieThérapie cibléeToxicityToxicité

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Pharmacology

Background:

  • Radiotherapy and targeted therapies are crucial in cancer management.
  • Current data on the combined toxicity and efficacy of these treatments are limited and fragmented.
  • A comprehensive review is needed to understand the risks and benefits of combining radiotherapy with targeted therapies.

Purpose of the Study:

  • To conduct a literature review on the risks and opportunities of combining radiotherapy with targeted therapies.
  • To consolidate existing knowledge on the synergistic effects and toxicities of combined treatment modalities.
  • To identify gaps in current research and highlight areas for future investigation.

Main Methods:

  • Searched major databases (EMBASE, ClinicalTrials.gov, Medline, Web of Science) for relevant studies.
  • Utilized a comprehensive list of keywords including radiotherapy, radiosurgery, and specific targeted therapy drug names (e.g., cetuximab, trastuzumab, vemurafenib) and targets (e.g., EGFR, ALK, BRAF).
  • Included terms related to targeted therapy classes like tyrosine kinase inhibitors (TKIs) and antibody-drug conjugates (ADCs).

Main Results:

  • A limited number of trials suggest a synergistic effect between radiotherapy and targeted therapies.
  • Mitogen-activated protein kinase (MAPK) inhibitors, when used in combination, exhibit known toxicities with established clinical guidelines.
  • The review identified a promising but underexplored landscape for combined cancer treatments.

Conclusions:

  • The current body of evidence provides a preliminary view of the combined use of radiotherapy and targeted therapies.
  • Significant limitations exist due to the scarcity of robust data.
  • Further high-quality research is essential to fully realize the potential of these combined therapeutic strategies in oncology.