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C-reactive protein in dogs.

D Caspi, F W Snel, R M Batt

    American Journal of Veterinary Research
    |June 1, 1987
    PubMed
    Summary
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    Serum C-reactive protein (CRP) levels in dogs can vary significantly. Elevated CRP concentrations indicate inflammation and disease activity in canine patients.

    Area of Science:

    • Veterinary Medicine
    • Immunology
    • Biochemistry

    Background:

    • C-reactive protein (CRP) is a key acute-phase protein in dogs.
    • Understanding CRP's behavior is crucial for diagnosing canine diseases.

    Purpose of the Study:

    • To measure serum CRP concentrations in healthy dogs and dogs with various conditions.
    • To evaluate CRP as an indicator of inflammation and disease in dogs.

    Main Methods:

    • Serum CRP levels were quantified using a specific immunoassay.
    • Measurements were taken in healthy dogs, dogs undergoing surgery or inoculation, and dogs with various disorders.

    Main Results:

    • Healthy dogs showed variable CRP levels, with some exhibiting elevated concentrations.

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  • CRP levels increased significantly after procedures like ovariohysterectomy and orthopedic surgery.
  • Infection with Leptospira interrogans serovar canicola induced a notable CRP response.
  • CRP concentrations in diseased dogs ranged widely and correlated with disease extent and activity.

    • Conclusions:

    • Serum CRP is a sensitive and precise indicator of acute inflammation and disease in dogs.
    • CRP measurements can provide objective insights into the in vivo response to various stimuli and conditions in canine patients.