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Related Experiment Video

Updated: Aug 29, 2025

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Alendronate-functionalized double network hydrogel scaffolds for effective osteogenesis.

Guoke Tang1,2, Liang Zhu2, Weiheng Wang1

  • 1Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China.

Frontiers in Chemistry
|September 5, 2022
PubMed
Summary

A novel double-network hydrogel scaffold, combining methacrylated gelatin (GelMA) and alendronate (ALN)-modified oxidized alginate (OSA), promotes in situ bone regeneration. This advanced biomaterial offers pH-responsive degradation and controlled drug release for enhanced bone repair.

Keywords:
ALNDN hydrogelGelMAOSAosteogenic differentiationschiff base

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Artificial bone substitutes mimicking the extracellular matrix are crucial for bone repair.
  • Existing materials often face challenges in biomechanics, biodegradability, and bioactivity.
  • There is a need for advanced scaffolds that can promote in situ bone regeneration.

Purpose of the Study:

  • To develop a functional double-network (DN) hydrogel scaffold for in situ bone regeneration.
  • To enhance biomechanics, biodegradability, and bioactivity for improved bone repair.
  • To create a system for on-demand drug release and stem cell therapy in bone regeneration.

Main Methods:

  • Constructed a DN hydrogel by interspersing methacrylated gelatin (GelMA) into alendronate (ALN)-modified oxidized alginate (OSA) networks.
  • Utilized Schiff base reaction and photo-crosslinking for hydrogel formation.
  • Investigated the hydrogel's properties, including network structure, pores, biocompatibility, biomechanics, pH-responsive biodegradation, and drug release.

Main Results:

  • The GelMA@OSA-ALN DN hydrogel exhibited favorable network and pore structures, good biocompatibility, and enhanced biomechanics.
  • The Schiff base linkage enabled pH-responsive biodegradation and sustained release of ALN.
  • The hydrogel promoted cell viability, growth, proliferation, and osteogenic differentiation, upregulating osteogenesis-related genes.

Conclusions:

  • The developed DN hydrogel scaffold offers a promising strategy for in situ bone regeneration.
  • The scaffold's properties facilitate effective bioactivity and controlled drug delivery.
  • This functional hydrogel holds potential for minimally invasive gelling systems for treating bone-related diseases.