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Just When We Thought That COVID Was Over: A Systematic Review
Maha Tariq1, Maitri V Acharekar1, Sara E Guerrero Saldivia1
1Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Many COVID-19 survivors experience persistent neurological and muscular symptoms, impacting their quality of life. This review highlights the long-term effects on these systems in long COVID patients.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- COVID-19 can lead to persistent debilitating symptoms in a significant number of recovered patients.
- Long-term neurological and psychiatric issues are frequently reported, lasting weeks to months post-infection.
- The impact on the central nervous system and muscular system warrants focused investigation in long COVID.
Purpose of the Study:
- To review and synthesize existing literature on the long-term neurological and muscular effects of COVID-19.
- To identify key symptoms and factors contributing to prolonged COVID-19 (long COVID).
- To emphasize the impact of these persistent symptoms on patients' quality of life.
Main Methods:
- Systematic review of 29 studies.
- Inclusion and exclusion criteria applied for study selection.
- Quality appraisal of selected studies involving 6012 patients.
Main Results:
- Long-term effects on the central nervous system and muscular system are prevalent in long COVID.
- Debilitating symptoms significantly affect patients' quality of life.
- Underlying pathophysiologic manifestations and patient-specific factors contribute to symptom persistence.
Conclusions:
- Long COVID significantly impacts the central nervous system and muscular system, affecting quality of life.
- Further research is needed to understand ethnic and gender disparities, and treatment efficacy for long COVID symptoms.
- A multidisciplinary specialist team approach is crucial for managing post-COVID conditions.
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