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Aging conundrum: A perspective for ovarian aging
Jiachen Wu1, Yang Liu1, Yinhua Song1
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in Endocrinology
|September 5, 2022
Summary
Aging causes functional decline and disease susceptibility. This review focuses on ovarian aging, its mechanisms, and interventions like stem cells and cryopreservation to delay reproductive aging.
Area of Science:
- Gerontology and Reproductive Biology
- Cellular and Molecular Mechanisms of Aging
Background:
- Aging is a universal process characterized by physiological decline and increased disease risk.
- The ovary ages prematurely, marked by reduced oocyte number and quality, impacting female reproductive health.
- Understanding ovarian aging mechanisms is crucial for reproductive longevity and health.
Purpose of the Study:
- To review the hallmarks of aging in the context of ovarian aging.
- To elucidate the clinical symptoms and underlying molecular mechanisms of ovarian aging.
- To explore potential interventions for delaying ovarian aging.
Main Methods:
- Comprehensive literature review of aging hallmarks and ovarian aging.
- Analysis of regulatory mechanisms and clinical manifestations of ovarian aging.
- Evaluation of current and emerging intervention strategies.
Main Results:
- Ovarian aging is characterized by a decline in oocyte quantity and quality.
- Key aging hallmarks contribute to ovarian functional deterioration.
- Various molecular pathways underlie ovarian aging, requiring further elucidation.
Conclusions:
- Ovarian aging is a critical aspect of female aging, necessitating targeted research.
- Intervention strategies, including stem cell therapy and cryopreservation, show promise in mitigating ovarian aging.
- Further research into regulatory mechanisms can lead to effective strategies for preserving reproductive function.
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