Liver Failure in Neonates With G6PD Deficiency

Area of Science:

• Biochemistry
• Pediatrics
• Hepatology

Background:

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common inherited red blood cell disorder.
• While associated with hemolysis and jaundice, its role in severe liver dysfunction, particularly liver failure, is not well-established.

Observation:

• Two neonates with G6PD deficiency presented with progressive liver failure.
• The liver failure was unresponsive to ursodiol treatment.

Findings:

• G6PD deficiency was linked to severe, treatment-resistant liver failure in these neonates.
• Both infants ultimately required liver transplantation due to the severity of their condition.

Implications:

• Highlights the critical need for vigilant liver function monitoring in jaundiced neonates with G6PD deficiency.
• Suggests that G6PD deficiency can precipitate or exacerbate severe liver disease, potentially leading to liver failure.