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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through

Ne N Wu1, Yaguang Bi1, Amir Ajoolabady1

  • 1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

JACC. Basic to Translational Science
|September 5, 2022
PubMed

Keywords:
AMCM, adult murine cardiomyocyteBP, blood pressureCa2+ overloadHFD, high-fat dietLFD, low-fat dietLV, left ventricularMCU, mitochondrial Ca2+ uniporterPA, palmitic acidParkinROS, reactive oxygen speciesTR90, time to 90% relengtheningVDAC, voltage-dependent anion channelVDAC1WT, wild-typehearthigh-fat dietmPTP, mitochondrial permeability transition poremitochondria

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