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Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress
Yihong Chen1,2, Junyan Shen1,3, Anna Hultgårdh Nilsson1
1Department of Experimental Medical Science, Lund University, Lund, Sweden.
JACC. Basic to Translational Science
|September 5, 2022
Abstract:
Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.
Keywords:
AU, arbitrary unitBrdU, bromodeoxyuridineCVD, cardiovascular diseaseEC, endothelial cellHCASMC, human coronary artery smooth muscle cellHDL, high-density lipoproteinHGF, hepatocyte growth factorHUVEC, human umbilical cord endothelial cellICD-9, International Classification of Diseases-9th RevisionIL, interleukinLDL, low-density lipoproteinMMP, matrix metalloproteinasePlGF, placental growth factorSMC, smooth muscle cellTGF, transforming growth factorTNF, tumor necrosis factorTRAIL, tumor necrosis factor–related apoptosis-inducing ligandVEGF, vascular endothelial growth factorapoptosisatherosclerosisendothelial cellsgrowth factorsinjurymRNA, messenger RNAmyocardial infarctions, solublesi-HGF, hepatocyte growth factor small interfering RNAsiRNA, small interfering RNA
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