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"Jianbing" styling multifunctional electrospinning composite membranes for wound healing
Hanqiang Zhao1, Youguang Xu2, Saisai Wang1
1School of Pharmacy, Weifang Medical University, Weifang, Shandong, China.
Frontiers in Bioengineering and Biotechnology
|September 5, 2022
Summary
A novel composite wound nano-dressing effectively combats infection and manages excess fluid. This antibacterial dressing promotes healing by inhibiting bacteria and aiding in fluid removal for better wound care.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Nanotechnology in Medicine
Background:
- Wound infections and excessive exudate impede effective wound healing.
- Existing antimicrobial dressings often fail to adequately remove biological fluids.
- A need exists for advanced wound dressings that address both infection and exudate management.
Purpose of the Study:
- To develop a composite wound nano-dressing with antibacterial and unidirectional fluid removal capabilities.
- To create a dual-layer dressing inspired by 'Chinese Jianbing' structure.
- To evaluate the in vitro and in vivo performance of the novel dressing.
Main Methods:
- Fabrication of a composite nano-dressing (PPCP) using casting and electrospinning.
- Hydrophilic outer layer: Chitosan & Polyvinyl Alcohol (CTS-PVA).
- Hydrophobic inner layer: Propolis & Polycaprolactone (PRO-PCL).
Main Results:
- The PRO-PCL and CTS-PVA (PPCP) dressing demonstrated potent inhibition of *Pseudomonas aeruginosa* in vitro.
- PPCP exhibited excellent antioxidant and hemostatic properties, with significant water absorption for exudate removal.
- In vivo studies showed anti-inflammatory effects, promotion of collagen I, and 80% wound healing by day 7.
Conclusions:
- The developed PPCP wound dressing offers a promising solution for managing wound infections and excess biofluids.
- Its unique composite structure facilitates effective antibacterial action and unidirectional exudate management.
- This novel dressing presents a new therapeutic option for advancing wound healing strategies.