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Related Experiment Video

Updated: Aug 29, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Research progress on detachable microneedles for advanced applications.

SeungHyun Park¹, KangJu Lee², WonHyoung Ryu¹

¹Department of Mechanical Engineering, Yonsei University, Republic of Korea.

Expert Opinion on Drug Delivery

|September 5, 2022

Summary

Detachable microneedles (DeMNs) overcome limitations of traditional patches by allowing substrate removal after drug delivery. This innovation enhances patient compliance and expands microneedle applications for various therapies.

Keywords:

advanced molding detachable microneedles microfabrication separation mechanism therapeutic agents

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Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Area of Science:

Biomaterials Science
Drug Delivery Systems
Regenerative Medicine

Background:

Microneedles (MNs) show promise in transdermal drug delivery, with current applications in cosmetics and vaccines.
Existing MN patches require prolonged application, reducing patient compliance and limiting use for diverse conditions.
Research is actively pursuing solutions to enhance MN applicability and patient adherence.

Purpose of the Study:

To review recent advancements in detachable microneedles (DeMNs).
To categorize DeMNs based on their detachment mechanisms.
To highlight the therapeutic potential and application sites of DeMNs.

Main Methods:

Review of current literature on microneedle technology.
Categorization of DeMNs into four types: substrate-separable, multi-layered, crack-inducing, and shell.
Analysis of DeMN applications for various therapeutic agents and tissues.

Main Results:

Detachable microneedles (DeMNs) have been developed using advanced biomaterials and fabrication techniques.
Four distinct types of DeMNs are identified, each with unique detachment strategies.
DeMNs effectively deliver a wide range of therapeutic agents, including drugs, proteins, and stem cells, to both dermal and non-dermal tissues.

Conclusions:

DeMNs represent a significant advancement over conventional MN patches.
The detachability feature of DeMNs improves patient compliance and broadens therapeutic possibilities.
Future innovations in DeMN design, fabrication, and materials are anticipated to further expand their clinical utility.