Liver function abnormalities are common in congestive heart failure patients, often mild and not indicating liver disease. Reduced cardiac index and congestion contribute to these biochemical changes.
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2018
Area of Science:
Cardiology
Hepatology
Internal Medicine
Background:
Congestive heart failure (CHF) can impact systemic hemodynamics.
Liver function abnormalities are a potential complication of CHF.
Purpose of the Study:
To investigate the incidence and severity of liver function abnormalities in patients with CHF.
To correlate these abnormalities with hemodynamic parameters.
Main Methods:
Analysis of systemic hemodynamics and biochemical profiles in 133 CHF patients.
Patients categorized into three groups based on cardiac index (CI) severity.
Linear regression analysis to assess correlations between pressures, CI, and liver function.
Main Results:
Mild liver function test elevations (alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin) and decreased albumin observed in mild to moderate CHF groups.
Severe CHF group (CI ≤ 1.5 L/min/m²) showed significantly elevated aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and total bilirubin.
Abnormalities in liver function tests ranged from 27% to 80% in the severe CHF group.
Hemodynamic parameters (right atrial pressure, pulmonary wedge pressure, CI) correlated with liver function abnormalities, but with small coefficients.
Conclusions:
Liver function abnormalities are common in CHF patients.
These abnormalities are generally mild and not indicative of clinically apparent hepatic disease.
Reduced forward flow and passive backward congestion are likely contributors to biochemical changes, with potential non-hemodynamic factors also involved.
