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Dual-zone material assignment method for correcting partial volume effects in image-based bone models.

Brendan Inglis1, Daniel Grumbles1, Hannah L Dailey1

  • 1Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania, USA.

Computer Methods in Biomechanics and Biomedical Engineering
|September 5, 2022
PubMed
Summary
This summary is machine-generated.

Partial volume effects in bone finite element analysis were mitigated using a dual-zone material model. This approach improved the accuracy of virtual mechanical testing, making it a reliable surrogate for physical biomechanical tests.

Keywords:
Finite element analysiscomputed tomographycortical bonevirtual mechanical testing

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Area of Science:

  • Biomechanics
  • Medical Imaging
  • Finite Element Analysis

Background:

  • Partial volume effects (PVEs) in image-based finite element analysis (FEA) of bone arise from image blur and reconstruction artifacts.
  • These PVEs can lead to inaccurate predictions of bone mechanical properties, such as torsional rigidity.

Purpose of the Study:

  • To develop and validate a material assignment approach to mitigate partial volume effects in bone FEA.
  • To improve the correlation between virtual mechanical testing and physical biomechanical testing.

Main Methods:

  • Physical torsion testing of 20 Swiss alpine sheep tibiae.
  • Creation of finite element models from micro-CT scans using tetrahedral and hexahedral elements.
  • Implementation of a dual-zone material model to differentiate bone from soft tissue based on voxel density.

Main Results:

  • FE models without PVE management over-predicted torsional rigidity compared to physical tests.
  • The dual-zone material model, after inverse optimization, showed strong correlations and high absolute agreement between virtual and physical tests.
  • Recommended parameters for the dual-zone model: 665 mgHA/cm³ cutoff density, 50 MPa soft tissue modulus, and 10,225 MPa-cm³/mgHA density-modulus slope for bone.

Conclusions:

  • Appropriate partial volume management is crucial for accurate image-based FEA of bone.
  • The dual-zone material model effectively mitigates PVEs, enabling virtual mechanical testing to reliably surrogate physical testing.
  • The proposed dual-zone material model provides flexibility across different element types for ovine tibiae analysis.