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Non-coding RNAs in diseases with a focus on osteoarthritis

Aneta Pekáčová1,2, Jiří Baloun1, Xiao Švec1

  • 1Institute of Rheumatology, Prague, Czech Republic.

Wiley Interdisciplinary Reviews. RNA
|September 5, 2022
PubMed

Insights

Osteoarthritis (OA) is common, but lacks biomarkers and treatments. Epigenetic factors, especially non-coding RNAs, offer new insights into OA development, prediction, and potential therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Osteoarthritis (OA) is a prevalent musculoskeletal disorder impacting millions globally.
  • Current understanding of OA pathogenesis lacks effective prognostic biomarkers and targeted treatments.
  • Epigenetic factors are emerging as key regulators in disease development.

Purpose of the Study:

  • To review the current knowledge on epigenetic factors in osteoarthritis.
  • To focus on the role of non-coding RNAs in OA development, prediction, and treatment.

Main Methods:

  • Literature review of recent research on epigenetics and osteoarthritis.
  • Focus on non-coding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, piwi-interacting RNAs, and small nucleolar RNAs.
  • Analysis of how these molecules regulate intracellular pathways relevant to OA.

Main Results:

  • Non-coding RNAs play crucial roles in intracellular signaling and biological processes.
  • Emerging technologies facilitate the detection and study of these epigenetic factors.
  • Non-coding RNAs are implicated in the development, prediction, and potential treatment of OA.

Conclusions:

  • Epigenetic regulation, particularly by non-coding RNAs, is critical in osteoarthritis.
  • Further research into non-coding RNAs may lead to novel diagnostic and therapeutic strategies for OA.
  • This review highlights the potential of non-coding RNAs as therapeutic targets for osteoarthritis.
Keywords:
biomarkerepigenetic factorsnon-coding RNAosteoarthritistargeted treatment

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