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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Anti-lung cancer properties of cyanobacterial bioactive compounds
Mirza S Baig1, Sajjan Rajpoot2, Tomokazu Ohishi3
1Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol, 453552, Indore, India. msb.iit@iiti.ac.in.
Abstract:
Lung cancer, the most prevalent gender-independent tumor entity in both men and women, is among the leading cause of cancer-related deaths worldwide. Despite decades of effort in developing improved therapeutic strategies including immunotherapies and novel chemotherapeutic agents, only modest improvements in outcome and long-term survival of lung cancer patients have been achieved. Therefore, exploring new and exceptional sources for bioactive compounds that might serve as anti-cancer agents might be the key to improving lung cancer therapy. On account of diverse forms, cyanobacteria might serve as a potential source for compounds with potential therapeutic applicability against malignant disorders, including cancer. The assorted arrays of metabolic mechanisms synthesize a plethora of bioactive compounds with immense biological potential. These compounds have been proven to be effective against various cancer cell lines and xenograft animal models. The present review provides an overview of the most promising cyanobacteria-derived bioactive compounds proven to exhibit anti-cancer properties in in-vitro and in-vivo studies and highlights their applicability as potential therapeutic agents with a focus on their anti-lung cancer properties.
Insights
Cyanobacteria offer promising bioactive compounds for novel lung cancer therapies. These natural compounds show potential in fighting cancer cells and improving patient outcomes.
Area of Science:
- Marine Biology
- Pharmacology
- Oncology
Background:
- Lung cancer remains a leading cause of cancer deaths globally, with limited therapeutic advancements.
- Current treatments like immunotherapy and chemotherapy offer modest improvements in patient survival.
- Novel therapeutic strategies are crucial for enhancing lung cancer treatment outcomes.
Purpose of the Study:
- To review promising cyanobacteria-derived compounds with anti-cancer properties.
- To highlight the potential of these compounds as therapeutic agents against lung cancer.
- To explore new sources for effective lung cancer treatments.
Main Methods:
- Literature review of in-vitro and in-vivo studies.
- Analysis of bioactive compounds synthesized by cyanobacteria.
- Focus on anti-lung cancer properties of identified compounds.
Main Results:
- Cyanobacteria produce diverse bioactive compounds with significant anti-cancer potential.
- These compounds have demonstrated efficacy against various cancer cell lines and in animal models.
- Several cyanobacteria-derived agents show promise for anti-lung cancer applications.
Conclusions:
- Cyanobacteria represent a valuable and largely untapped resource for discovering novel anti-cancer drugs.
- Bioactive compounds from cyanobacteria warrant further investigation for their therapeutic potential in lung cancer.
- Exploring natural sources like cyanobacteria is key to developing next-generation lung cancer therapies.
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