Anti-lung cancer properties of cyanobacterial bioactive compounds

Mirza S Baig1, Sajjan Rajpoot2, Tomokazu Ohishi3

  • 1Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol, 453552, Indore, India. msb.iit@iiti.ac.in.

Archives of Microbiology
|September 5, 2022
PubMed

Insights

Cyanobacteria offer promising bioactive compounds for novel lung cancer therapies. These natural compounds show potential in fighting cancer cells and improving patient outcomes.

Area of Science:

  • Marine Biology
  • Pharmacology
  • Oncology

Background:

  • Lung cancer remains a leading cause of cancer deaths globally, with limited therapeutic advancements.
  • Current treatments like immunotherapy and chemotherapy offer modest improvements in patient survival.
  • Novel therapeutic strategies are crucial for enhancing lung cancer treatment outcomes.

Purpose of the Study:

  • To review promising cyanobacteria-derived compounds with anti-cancer properties.
  • To highlight the potential of these compounds as therapeutic agents against lung cancer.
  • To explore new sources for effective lung cancer treatments.

Main Methods:

  • Literature review of in-vitro and in-vivo studies.
  • Analysis of bioactive compounds synthesized by cyanobacteria.
  • Focus on anti-lung cancer properties of identified compounds.

Main Results:

  • Cyanobacteria produce diverse bioactive compounds with significant anti-cancer potential.
  • These compounds have demonstrated efficacy against various cancer cell lines and in animal models.
  • Several cyanobacteria-derived agents show promise for anti-lung cancer applications.

Conclusions:

  • Cyanobacteria represent a valuable and largely untapped resource for discovering novel anti-cancer drugs.
  • Bioactive compounds from cyanobacteria warrant further investigation for their therapeutic potential in lung cancer.
  • Exploring natural sources like cyanobacteria is key to developing next-generation lung cancer therapies.

Related Concept Videos

Bacterial Phylum Cyanobacteria01:30

Bacterial Phylum Cyanobacteria

Cyanobacteria are a diverse group of oxygenic, phototrophic bacteria that played a pivotal role in converting Earth’s atmosphere from anoxic to oxygen-rich billions of years ago. They exhibit remarkable morphological diversity, ranging from unicellular forms to filamentous types, with cell sizes varying between 0.5 μm and 100 μm. Cyanobacteria are classified into five groups: Chroococcales (unicellular, dividing by binary fission), Pleurocapsales (unicellular, dividing by...
91
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
14.9K
Bioremediation00:46

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
19.8K