Related Experiment Videos
Immuno-Metabolic Reprogramming in Metabolic Syndrome and Its Cardiovascular Complications: An Integrative
Komal Shrivastav1,2, Sushama Jadhav3, Pratik Mahajan4
1ICMR-National Institute for Tribal Health Research (NITHR), Jabalpur 482003, India.
International Journal of Molecular Sciences
|July 15, 2026
Summary
Metabolic syndrome and diabetic coronary artery disease share immune-inflammatory pathways. Key genes like CD86 and CD33, and miRNAs, may be therapeutic targets for these conditions.
Area of Science:
- Cardiovascular Science
- Immunology
- Genomics
Background:
- Metabolic syndrome (MeS) is a significant risk factor for cardiovascular disease, involving inflammation and metabolic issues.
- The molecular links between MeS and diabetic coronary artery disease (DMCAD) are not fully understood.
Purpose of the Study:
- To elucidate the molecular mechanisms connecting MeS to DMCAD using bioinformatics.
- To identify potential biomarkers and therapeutic targets for inflammation-driven cardiometabolic diseases.
Main Methods:
- Analysis of peripheral blood mononuclear cell transcriptomic data from MeS and DMCAD patients.
- Utilized differential gene expression, pathway enrichment, protein-protein interaction networks, WGCNA, GSEA, and miRNA regulatory network analysis.
- Validated candidate genes using an independent type 2 diabetes mellitus dataset.
Main Results:
- Identified immune-inflammatory and immuno-metabolic pathways as central to both MeS and DMCAD.
- Highlighted key hub genes (CD86, CD33, CCR1, C5AR1, FPR1, CXCL16, LILRA5) involved in immune regulation and cardiometabolic dysfunction.
- Identified miR-17/92 family and miR-146a-5p as potential upstream regulators, linked to inflammation and angiogenesis.
Conclusions:
- Coordinated immune-inflammatory and metabolic signaling networks drive the progression from MeS to DMCAD.
- Identified hub genes and miRNAs represent potential biomarkers and therapeutic targets for inflammation-driven cardiometabolic diseases.
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...