[Morphogenesis of hepatocellular necrosis in patients with cholelithiasis complicated by gangrenous cholecystitis]

Morphogenesis of hepatocellular necrosis was studied on liver biopsy samples from patients with cholelithiasis complicated with gangrenous cholecystitis. In patients operated on 5-7 days after the onset on the disease there were foci of hepatic parenchyma necrosis infiltrated with polymorphonuclear leukocytes (PNL) with relevant introduction into the hepatocytes. In patients operated on in 10-15 days disintegration of cellular structures, removal of necrotic masses and reparation proceed with participation of PNL in line with tissue macrophages and stellate reticuloendotheliocytes, poorly differentiated and mature fibroblast-like cells. Finally, bundles of collagen fibres are forming and introduced at the sites of hepatocellular necrosis.