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Human seminal virome: a panel based on recent literature
Beatriz Helena Dantas Rodrigues de Albuquerque1, Maryana Thalyta Ferreira Camara de Oliveira1, Janaína Ferreira Aderaldo1,2,3
1Laboratório de Biologia Molecular Aplicada - LAPLIC, Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, CEP: 59072-970, Brazil.
Basic and Clinical Andrology
|September 5, 2022
Summary
The human seminal virome is poorly understood, but new research identifies viruses impacting male fertility. A proposed panel aids in evaluating semen quality and investigating infertility causes.
Area of Science:
- Virology
- Reproductive Medicine
- Genitourinary Health
Background:
- The human seminal virome and its impact on male fertility are not well-defined.
- Current diagnostic methods lack comprehensive panels for detecting clinically relevant seminal viruses.
Purpose of the Study:
- To characterize the human seminal virome by analyzing extensive scientific literature.
- To identify viruses associated with diminished seminal parameters and male infertility.
- To propose a diagnostic panel for seminal viruses impacting male reproductive health.
Main Methods:
- Comprehensive literature review and analysis of over 1,000 studies published within the last five years.
- Systematic evaluation of viral presence in seminal samples.
- Correlation analysis between specific viruses and observed seminal parameter changes.
Main Results:
- A significant increase in research on viruses in human semen has been observed.
- Studies predominantly focus on prospective investigations or specific clinical conditions.
- Identification of key viruses linked to the deterioration of seminal quality and male fertility.
Conclusions:
- The analysis highlights viruses negatively affecting seminal parameters and male fertility.
- A novel panel of significant seminal viruses is proposed for clinical use.
- This panel can enhance semen quality assessment and serve as a diagnostic tool for infertility investigations.
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