Related Experiment Video
Updated: Aug 29, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility
Georgios Voloudakis1,2,3,4,5,6,7, James M Vicari8,9,10,11,12,13, Sanan Venkatesh8,9,10,11,12,13,14
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.
Abstract:
Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes that reduce COVID-19 host susceptibility is a critical next step. Using a translational genomics approach that integrates COVID-19 genetic susceptibility variants, multi-tissue genetically regulated gene expression (GReX), and perturbagen signatures, we identified IL10RB as the top candidate gene target for COVID-19 host susceptibility. In a series of validation steps, we show that predicted GReX upregulation of IL10RB and higher IL10RB expression in COVID-19 patient blood is associated with worse COVID-19 outcomes and that in vitro IL10RB overexpression is associated with increased viral load and activation of disease-relevant molecular pathways.
More Related Videos
Related Concept Videos
Leaky Scanning
Single Nucleotide Polymorphisms-SNPs
Ribosome Profiling
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
MicroRNAs

