Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulation threshold functions for chronically impaired Menière patients.

C Formby

    Audiology : Official Organ of the International Society of Audiology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adaptive plasticity of loudness induced by chronic attenuation and enhancement of the acoustic background.

    The Journal of the Acoustical Society of America·2003
    Same author

    Temporal integration of sinusoidal increments in the absence of absolute energy cues.

    Journal of speech, language, and hearing research : JSLHR·2003
    Same author

    Exponential processes in human auditory excitation and adaptation.

    Hearing research·2002
    Same author

    Celebrating a decade of evaluation and treatment: the University of Maryland Tinnitus & Hyperacusis Center.

    American journal of audiology·2001
    Same author

    Measurement of vestibular ocular reflex (VOR) time constants with a caloric step stimulus.

    Journal of vestibular research : equilibrium & orientation·2000
    Same author

    Enhancements of the edges of temporal masking functions by complex patterns of overshoot and undershoot.

    The Journal of the Acoustical Society of America·2000
    Same journal

    Apoptosis in the OC-k3 immortalized cell line treated with different agents.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Age-related histopathological changes of the stria vascularis: an experimental model.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Anatomical, metabolic and genetic aspects of age-related hearing loss in mice.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Effect of ageing on otoacoustic emissions and efferent suppression in humans.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Cochlear function and speech recognition in the elderly.

    Audiology : official organ of the International Society of Audiology·2002
    Same journal

    Determination and classification of the problems experienced by hearing-impaired elderly people.

    Audiology : official organ of the International Society of Audiology·2002
    See all related articles

    Menière disease patients show normal sound modulation detection in their better ear but deficits in their poorer ear. Poorer ear sensitivity declines significantly at higher modulation frequencies, suggesting broadened peripheral tuning.

    Area of Science:

    • Audiology
    • Neuroscience
    • Otolaryngology

    Background:

    • Menière disease is a disorder of the inner ear.
    • It is characterized by fluctuating hearing loss, tinnitus, vertigo, and aural fullness.
    • The underlying pathophysiology is thought to involve endolymphatic hydrops.

    Purpose of the Study:

    • To investigate the impact of Menière disease on the ability to detect amplitude modulation in sound.
    • To compare modulation detection thresholds between the better and poorer ears of patients with Menière disease.
    • To explore the relationship between Menière disease and peripheral auditory tuning.

    Main Methods:

    • Detection thresholds for sinusoidally amplitude-modulated broad-band noise were measured.
    • Measurements were conducted as a function of modulation frequency.

    Related Experiment Videos

  • An adaptive cued-standard forced-choice psychophysical method was employed.
  • Data were collected for both ears of 6 chronic Menière patients.

    • Main Results:

    • Better-ear modulation thresholds were comparable to normative data.
    • Five out of six patients demonstrated deficits in modulation detection in their poorer ears.
    • Poorer ear sensitivity declined at higher modulation frequencies (above 60-100 Hz) at approximately twice the normal rate.
    • Poorer ear data fit a low-pass filter model with a 60 Hz cutoff frequency.

    Conclusions:

    • Menière disease can cause specific deficits in auditory processing, particularly in the poorer ear.
    • The observed pattern of reduced sensitivity to modulation is consistent with broadened peripheral tuning.
    • This broadening is likely a consequence of endolymphatic hydrops affecting the inner ear's mechanical properties.