The Relationship between Serum CXCL8 and ET-1 Expression Levels and Sepsis Complicated with Heart Failure
Jianlong Zhu1, Changjun Song2, Tingting Cai3
1Department of Critical Care Medicine, Ganzhou People's Hospital, Ganzhou 341000, China.
Insights
Sepsis patients with heart failure show higher levels of CXC chemokine ligand 8 (CXCL8) and endothelin-1 (ET-1). These biomarkers are risk factors for developing heart failure in sepsis.
Area of Science:
- Biochemistry
- Cardiology
- Critical Care Medicine
Background:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Heart failure is a common and severe complication of sepsis, significantly increasing mortality rates.
- Understanding the molecular mechanisms underlying sepsis-induced heart failure is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the relationship between sepsis complicated with heart failure and the expression levels of CXC chemokine ligand 8 (CXCL8) and endothelin-1 (ET-1).
- To identify potential biomarkers for predicting heart failure in sepsis patients.
Main Methods:
- A cohort of 128 sepsis patients were divided into simple sepsis and complicated heart failure groups.
- Serum levels of CXCL8 and ET-1 were measured using ELISA.
- Cardiac function parameters including LVEF, SV, CO, and CI were assessed by color Doppler ultrasound.
- Correlation and logistic regression analyses were performed to evaluate the association between biomarkers, clinical data, and heart failure development.
Main Results:
- Patients with sepsis complicated by heart failure exhibited significantly higher serum levels of CXCL8 and ET-1 compared to those with simple sepsis.
- Elevated CXCL8 and ET-1 levels were positively correlated with disease severity scores (SOFA, APACHE II) and negatively correlated with cardiac function parameters (LVEF, SV, CO, CI).
- CXCL8 and ET-1 were identified as independent risk factors for sepsis complicated with heart failure.
Conclusions:
- Serum CXCL8 and ET-1 expression levels are significantly elevated in sepsis patients who develop heart failure.
- CXCL8 and ET-1 serve as important indicators and risk factors for heart failure in the context of sepsis.
Objective:
The objective is to investigate the relationship between sepsis complicated with heart failure and the expression levels of CXC chemokine ligand 8 (CXCL8) and endothelin-1 (ET-1).
Methods:
A total of 128 sepsis patients accepted by the Ganzhou People's Hospital from March 2019 to December 2021 were collected as observation objects, and they were separated into a simple sepsis group (86 cases) and a complicated heart failure group (42 cases) according to whether they were accompanied by heart failure or not. General data such as Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation II (APACHE II) were collected; the expression levels of serum CXCL8 and ET-1 were detected by enzyme-linked immunosorbent assay (ELISA); the cardiac function parameters such as left ventricular ejection fraction (LVEF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) were measured by color Doppler ultrasound; the correlation between serum CXCL8 and ET-1 expression levels with clinical data and cardiac function parameters in patients with sepsis complicated with heart failure was analyzed by the Pearson correlation; and the influencing factors of sepsis complicated with heart failure were analyzed by the logistic regression analysis.
Results:
The serum CXCL8 and ET-1 expression levels, SOFA score, and APACHE II score in the complicated heart failure group were higher than those in the simple sepsis group (P < 0.05), and LVEF, SV, CO, and CI in the complicated heart failure group were lower than those in the simple sepsis group (P < 0.05). Serum CXCL8 was positively correlated with ET-1 in patients with sepsis complicated with heart failure (r = 0.531, P < 0.05), and the two were positively correlated with SOFA score and APACHE II score (P < 0.05) and were negatively correlated with LVEF, SV, CO, and CI (P < 0.05). CXCL8 and ET-1 were independent risk factors for sepsis complicated with heart failure (P < 0.05).
Conclusion:
The expression levels of serum CXCL8 and ET-1 in sepsis patients with heart failure are significantly increased, and both are risk factors for heart failure in sepsis patients.
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