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Updated: Aug 29, 2025

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
Published on: December 17, 2014
[Induced Pluripotent Stem Cell Therapy: A Novel Approach for Spinal Cord Injury]
Takahiro Kondo1, Hideyuki Okano
1Departments of Physiology, School of Medicine, Keio University.
Abstract:
We have performed extensive basic and preclinical research to investigate the role of human induced pluripotent cell-derived neural stem/progenitor cell (hiPSC-NS/PC) grafts in spinal cord injury (SCI) models, and evidence obtained from animal experiments confirms the safety and effectiveness of this approach. We have initiated a first-in-human clinical trial of hiPSC-NS/PC transplantation in patients with subacute SCI. Research on the therapeutic mechanism underlying stem cell transplantation therapy is ongoing worldwide; this paper outlines the current knowledge of the therapeutic mechanism.
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