Related Experiment Video
Updated: Aug 29, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
[Correlation between Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Signaling Pathway and Non-infectious
Hua-Xiang Yu1, Hai-Ying Rui1, Zi-Qi Han1
1Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine,Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province,Key Laboratory of Emergency and Critical Care Medicine of Shandong Province,Institute of Emergency and Critical Care Medicine of Shandong University,Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine,Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University,Jinan 250012,China.
Abstract:
As a DNA receptor in the cytoplasm,cyclic GMP-AMP synthase (cGAS) can recognize abnormal DNA in the cytoplasm and activate stimulator of interferon genes (STING) to regulate the immune response. The recent studies have demonstrated that this pathway plays a role in non-infectious inflammatory diseases by promoting the expression of type Ⅰ interferon and interferon-stimulated gene.This article reviews the activation and regulation of cGAS-STING pathway in multiple systems and the effect of this pathway on the occurrence and progression of non-infectious inflammatory diseases,providing theoretical reference for future application of cGAS-STING pathway-related drugs in non-infectious inflammatory diseases.
More Related Videos
10:00High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
Related Concept Videos
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Intracellular Signaling Cascades
The JAK-STAT Signaling Pathway
cAMP-dependent Protein Kinase Pathways
GPCRs Regulate Adenylyl Cylase Activity