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Association of Serum γ-Glutamyltransferase With C-Reactive Protein Levels in Patients With Coronary Heart Disease

Yuanyuan He1, Mengnan Huang1, Zhu Li1

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Angiology
|September 6, 2022
PubMed

Insights

Serum gamma-glutamyltransferase (GGT) levels are linked to C-reactive protein (CRP) in coronary heart disease (CHD) patients. Higher GGT levels significantly correlate with elevated CRP, suggesting GGT as a potential inflammatory marker for cardiovascular risk assessment.

Area of Science:

  • Cardiology
  • Biochemistry
  • Inflammation Research

Background:

  • Serum gamma-glutamyltransferase (GGT) and C-reactive protein (CRP) are established biomarkers.
  • Limited research exists on the GGT-CRP relationship specifically within coronary heart disease (CHD) populations.
  • Inflammation plays a critical role in the pathogenesis of CHD.

Purpose of the Study:

  • To investigate the association between serum GGT levels and CRP levels in a large cohort of patients with established CHD.
  • To determine if GGT can serve as an indicator of inflammation and cardiovascular risk in CHD patients.

Main Methods:

  • Retrospective analysis of 17,523 CHD patients who underwent GGT and CRP testing.
  • Patients categorized into three groups based on GGT tertiles.
  • Logistic regression analysis employed to assess the association between GGT and CRP, adjusting for relevant parameters.

Main Results:

  • A significant positive association was observed between serum GGT and CRP levels in CHD patients.
  • Patients in the highest GGT tertile (T3) had a significantly higher odds ratio (OR) for elevated CRP compared to the lowest tertile (T1) (OR: 2.15).
  • The association between GGT and CRP was pronounced in males compared to females.

Conclusions:

  • Serum GGT levels are significantly associated with CRP levels in patients with coronary heart disease.
  • GGT may function as a valuable inflammatory marker in CHD.
  • Elevated GGT could represent an additional tool for assessing cardiovascular risk in this patient group.

Keywords:
C-reactive proteincoronary heart diseaseγ-glutamyltransferase

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