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Updated: Aug 29, 2025

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Published on: July 29, 2021
Dermatologic Symptoms and Syndromes Associated with Headache
Arathi Nandyala1, Carrie Dougherty2
1Department of Neurology, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, 7-PHC, Washington, DC, 20007, USA.
Headache disorders can manifest with skin changes like rashes and bruising. This review explores the link between dermatologic conditions and headache, aiding diagnosis and management.
Area of Science:
- Neurology
- Dermatology
Background:
- Headache disorders frequently involve symptoms beyond the nervous system.
- Skin conditions are not typically considered common headache comorbidities.
Purpose of the Study:
- To review dermatologic presentations associated with headache disorders.
- To aid in the workup and management of headaches in patients with skin conditions.
Main Methods:
- Review of multiple articles and retrospective studies.
- Categorization of dermatologic presentations into ecchymoses, inflammatory skin conditions, and neurocutaneous disorders.
Main Results:
- Established association between head pain and dermatologic changes like ecchymoses, rashes, and neurocutaneous disorders.
- Postulated mechanisms involve trigeminal autonomic system activation and shared inflammatory pathways.
Conclusions:
- Dermatologic manifestations can be linked to headache disorders.
- Understanding these associations can guide clinical evaluation and treatment strategies.
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