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Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy

Sabya Sachi Das1, Sandeep Kumar Singh2, P R P Verma2

  • 1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology - Mesra, Ranchi 835215, Jharkhand, India; School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248009, Uttarakhand, India.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 6, 2022
PubMed

Insights

Inflammation significantly impacts cancer growth and treatment. Polyester nanoparticles offer a promising nanotechnology approach to overcome conventional chemotherapy limitations for inflammation-mediated cancers.

Area of Science:

  • Oncology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Inflammation plays a dual role in cancer progression, influencing tumor growth and therapeutic responses.
  • Key signaling pathways (NF-κB, STAT3) and factors (cytokines, VEGF, TGF-β) regulate inflammation in cancer.
  • Conventional chemotherapeutics face limitations like poor targeting, pharmacokinetics, and toxicity in inflammation-mediated cancers.

Purpose of the Study:

  • To review the therapeutic potential of polyester nanomaterials in targeting inflammation-mediated cancers.
  • To highlight how nanotechnology overcomes conventional chemotherapy drawbacks.
  • To discuss the role of polyester nanoparticles in modulating cancer-related inflammatory pathways.

Main Methods:

  • Literature review focusing on polyester nanomaterials (PLGA, PCL, PLA, PHA) for cancer therapy.
  • Analysis of studies investigating nanoparticle delivery systems for inflammation-mediated cancers.
  • Examination of signaling pathways targeted by these nanocarriers.

Main Results:

  • Polyester nanoparticles demonstrate improved drug delivery, stability, and targetability compared to conventional agents.
  • These systems can protect drugs from degradation and enhance solubility.
  • Nanoparticles reduce cytotoxicity by accumulating in cancer cells, sparing healthy tissues.

Conclusions:

  • Polyester-based nanoparticulate systems show significant therapeutic promise for inflammation-mediated cancers.
  • Nanotechnology offers a viable strategy to enhance the efficacy and safety of cancer therapeutics.
  • Targeting inflammation-related signaling pathways with polyester nanoparticles is a key area for future cancer treatment development.
Keywords:
AnticancerInflammatory signaling pathwaysNanomedicinePolyester nanomaterialsTargeted delivery

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