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[The immune system in coronary atherosclerosis].

S G Osipov, N I Bakhov, V I Rudnev

    Biulleten' Vsesoiuznogo Kardiologicheskogo Nauchnogo Tsentra AMN SSSR
    |January 1, 1987
    PubMed
    Summary

    Patients with coronary heart disease show an immune system imbalance with high B-cell activity and low T-cell function. This immune dysfunction occurs early, even before artery damage is visible, suggesting a functional form of atherosclerosis.

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    Area of Science:

    • Immunology
    • Cardiology
    • Pathophysiology

    Background:

    • Coronary heart disease (CHD) involves complex immune system dysregulation.
    • Understanding immune markers in early CHD is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the immune system's humoral and cellular factors in patients with coronary heart disease.
    • To determine if immunological imbalances precede or coincide with coronary artery lesions.

    Main Methods:

    • Analysis of humoral and cellular immunity components in CHD patients.
    • Comparison of immune profiles between patients with and without documented coronary atherosclerosis.

    Main Results:

    • A significant imbalance was observed, characterized by elevated B-cell activity and diminished T-cell function in CHD patients.

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  • This immunological imbalance was present in all clinically significant forms of CHD.
  • The immune alterations were detectable before the appearance of visible coronary artery lesions.

    • Conclusions:

    • The study identifies a distinct immunological profile in coronary heart disease patients.
    • Immune dysregulation, specifically high B-cell and low T-cell activity, is an early indicator of CHD.
    • Patients without angiographically confirmed atherosclerosis may have a functional form of the disease based on these immunological criteria.