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Proliferative Potential of Cardiomyocytes in Hypertrophic Cardiomyopathy: Correlation with Myocardial Remodeling

T V Sukhacheva1, Yu A Chudinovskikh2, M V Eremeeva2

  • 1A. N. Bakulev Scientific Center for Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia. tatiana@box.ru.

Bulletin of Experimental Biology and Medicine
|November 25, 2016
PubMed

Insights

Proliferating cardiomyocytes (Ki-67+) were found in adult hypertrophic cardiomyopathy patients. These cells indicate potential cardiomyocyte dedifferentiation and structural changes in the heart muscle.

Area of Science:

  • Cardiovascular Biology
  • Cellular Biology
  • Pathology

Background:

  • Hypertrophic cardiomyopathy (HCM) is characterized by cardiomyocyte hypertrophy.
  • The regenerative capacity and cellular dynamics of adult cardiomyocytes in HCM are not fully understood.
  • Understanding cardiomyocyte proliferation and differentiation is crucial for disease mechanisms.

Purpose of the Study:

  • To investigate the presence and characteristics of proliferating cardiomyocytes in adult patients with hypertrophic cardiomyopathy.
  • To correlate cardiomyocyte proliferation with the degree of hypertrophy and dedifferentiation.

Main Methods:

  • Immunohistochemistry for Ki-67 and sarcomeric α-actin.
  • Assessment of cardiomyocyte differentiation via myofibril content and ultrastructural morphology.
  • Analysis of connexin 43-containing gap junction distribution.

Main Results:

  • Proliferating Ki-67+ cardiomyocytes were identified in the interventricular septum of HCM patients.
  • A subset of these cells (Ki-67+/sarc α-act+) exhibited characteristics of early differentiation.
  • The presence of these proliferating cells correlated with significant cardiomyocyte hypertrophy and signs of dedifferentiation.

Conclusions:

  • Adult cardiomyocytes retain a proliferative capacity in the context of hypertrophic cardiomyopathy.
  • Proliferating cardiomyocytes in HCM may represent a response to injury or a mechanism of partial dedifferentiation.
  • These findings contribute to understanding the cellular plasticity and structural remodeling in hypertrophic cardiomyopathy.

Keywords:
connexin 43dedifferentiated cardiomyocyteshypertrophic cardiomyopathymyocardium of the interventricular septumproliferative activity of cardiomyocytes

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