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Published on: July 24, 2016
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Intraosseous infusion of acyclovir in a neonate
Saverio De Marca1, Matteo Calafatti2, Luciana Romaniello1
1Department of Neonatology and NICU, "San Carlo" Hospital, Potenza, Italy.
Italian Journal of Pediatrics
|September 6, 2022
Summary
Intraosseous (IO) access provides a rapid route for drug delivery when intravenous (IV) access fails in neonates. This case study demonstrates the successful use of IO acyclovir in a critically ill infant, highlighting its feasibility.
Area of Science:
- Neonatal Medicine
- Pharmacology
- Emergency Medicine
Background:
- Intraosseous (IO) access is a critical route for fluid and drug administration in critically ill neonates when intravenous (IV) access is unattainable.
- Limited data exists on the efficacy and safety of administering antiviral agents via the IO route in neonates.
Observation:
- A 2-week-old neonate in the Neonatal Intensive Care Unit (NICU) with suspected meningitis lost IV access.
- Acyclovir was successfully administered via IO infusion after peripheral and central venous access could not be established.
Findings:
- The IO administration of acyclovir was feasible and well-tolerated in this critically ill neonate.
- No adverse events or complications were observed during the 12-month follow-up period.
Implications:
- This case highlights the potential of IO acyclovir as a viable alternative in neonatal emergencies when IV access is compromised.
- Further research is warranted to establish IO administration protocols for antiviral medications in neonates.
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