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Smart biomaterials and their potential applications in tissue engineering.

Haider Mohammed Khan1, Xiaoxia Liao2, Bilal Ahmed Sheikh1

  • 1Department of Orthopedics, West China Hospital, Sichuan University, 610041, Chengdu, China. kongspine@126.com.

Journal of Materials Chemistry. B
|September 7, 2022
PubMed
Summary

Smart biomaterials are revolutionizing tissue engineering for bone, skin, and nerve regeneration. This review explores advanced materials and techniques for creating effective tissue scaffolds and conduits.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Smart biomaterials are crucial for tissue engineering, enabling novel tissue morphogenesis through cell interaction.
  • The review covers biomaterials for bone regeneration, skin grafts, and nerve conduits.

Purpose of the Study:

  • To review current smart biomaterials and techniques for bone, skin, and nerve tissue engineering.
  • To highlight material properties, interactions, and outcomes for various regenerative applications.

Main Methods:

  • Summarizing bioceramics and materials for bone scaffolds.
  • Outlining skin nanocomposites with antibacterial properties and regeneration therapies (infrared radiation, electrospinning, piezoelectricity).
  • Examining natural and synthetic polymers for artificial skin grafts and peripheral nerve conduits.

Main Results:

  • Biomaterials are being developed for bone scaffolds, antibacterial skin grafts, and artificial skin.
  • Natural and synthetic biomaterials show promise and limitations for nerve conduits.
  • Preclinical outcomes of nerve regeneration using natural conduits are detailed.

Conclusions:

  • Smart biomaterials, particularly at the nanomaterial-biological interface, are key to advancing tissue engineering.
  • Further research into material interactions and preclinical outcomes is essential for clinical translation.