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Stimuli-responsive delivery strategies for controllable gene editing in tumor therapeutics

Yu Ji1, Liansheng Fan1, Suchen Qu1

  • 1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. xhan0220@njucm.edu.cn.

Journal of Materials Chemistry. B
|September 7, 2022
PubMed

Insights

CRISPR delivery systems are crucial for tumor therapy. This review details stimuli-responsive nanocarriers designed for precise, controllable drug release, enhancing CRISPR

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Biology

Background:

  • CRISPR technology shows promise for cancer treatment.
  • Effective delivery vectors are essential for CRISPR applications.
  • Stimuli-responsive systems offer precise targeting for drug delivery.

Purpose of the Study:

  • To review the synthesis of stimuli-responsive nanocarriers for CRISPR delivery.
  • To discuss nanocarriers controlled by biochemical and physical signals.
  • To explore challenges and future prospects in nanocarrier development.

Main Methods:

  • Review of literature on stimuli-responsive nanocarrier synthesis.
  • Analysis of chemical structures enabling controllable release.
  • Discussion of nanocarrier control mechanisms (biochemical/physical signals).

Main Results:

  • Key chemical structures for stimuli-responsive nanocarriers are identified.
  • Nanocarriers can be designed for controlled release triggered by specific signals.
  • Both biochemical and physical stimuli can be utilized for nanocarrier activation.

Conclusions:

  • Stimuli-responsive nanocarriers are vital for precise CRISPR-based tumor therapy.
  • Designing nanocarriers with specific signal responses is key to controllable release.
  • Further research is needed to overcome challenges and advance nanocarrier technology.

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