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Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

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Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

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Published on: July 31, 2019

Aberrant Functional Lateralization and Interhemispheric Synergy in High Myopia: Insights From Neurotransmitter

Lin Zhou¹, Yuanyuan Wang², Shumin Xiong¹

¹Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.

Investigative Ophthalmology & Visual Science

|July 15, 2026

Summary

High myopia (HM) is linked to altered brain function, specifically in hemispheric lateralization and interhemispheric coordination. These changes may be associated with specific neurotransmitter systems, offering new insights into the disorder.

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Area of Science:

Neuroscience
Ophthalmology
Medical Imaging

Background:

High myopia (HM) is a severe ocular condition with potential for irreversible visual impairment.
Previous research indicates cerebral functional alterations in HM, but hemispheric asymmetry and interhemispheric coordination patterns are not well understood.

Purpose of the Study:

To investigate abnormalities in hemispheric lateralization and interhemispheric cooperation in patients with HM.
To explore potential neurotransmitter-related mechanisms underlying these functional anomalies.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was conducted on 55 HM patients and 55 controls.
Autonomy index (AI) and functional connectivity between homologous voxels (CFH) were measured.
Spatial correlation with neurotransmitter receptor/transporter density and support vector machine (SVM) classification were performed.

Main Results:

Widespread AI enhancement was observed in HM patients, notably in the right lingual and inferior temporal gyri.
Significantly attenuated CFH was found in bilateral fusiform/parahippocampal gyri and other homologous areas.
Anomalous regions correlated with serotonin, dopamine receptors, and acetylcholine transporter distribution; SVM achieved 72.73% classification accuracy.

Conclusions:

This study reveals abnormal functional lateralization and cooperation in HM patients.
These functional anomalies are proposed to have a specific neurochemical basis.
Findings provide insights into the pathophysiological mechanisms of high myopia.