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Updated: Aug 29, 2025

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems

Published on: March 3, 2010

Dual-mode nanophotonic upconversion oxygen sensors.

Esmaeil Heydari^1,2, Javad AmirAhmadi¹, Nahid Ghazyani¹

¹Faculty of Physics, Kharazmi University, Tehran, 15719-14911, Iran. e.heydari@khu.ac.ir.

|September 7, 2022

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This study presents a novel nanophotonic biosensor for real-time oxygen detection using near-infrared excitation. The developed sensor demonstrates enhanced sensitivity and performance, paving the way for implantable oxygen monitoring platforms.

Area of Science:

Nanophotonics
Biosensing
Materials Science

Background:

Near-infrared (NIR) excitable nanophotonic biosensors offer versatile applications.
Real-time oxygen detection is crucial in various scientific and medical fields.

Purpose of the Study:

To develop a 980 nm-excitable nanophotonic sensor for oxygen detection in water and air.
To investigate the enhanced oxygen sensitivity and performance of the developed sensor.

Main Methods:

Utilized a nanocomposite of lanthanide-doped NaYF4:Yb3+,Tm3+ upconversion nanoparticles and PtTFPP platinum porphyrin in a polystyrene matrix.
Analyzed photoluminescence (PL) lifetime and intensity for oxygen sensing.
Evaluated sensor performance including sensitivity, stability, reversibility, and temperature dependence.

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Last Updated: Aug 29, 2025

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems

Published on: March 3, 2010

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence

Published on: May 4, 2011

Triplet Fusion Upconversion Nanocapsule Synthesis

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

Main Results:

Achieved 68% efficient excitation of PtTFPP using a 980 nm NIR laser.
Demonstrated over a 10-fold boost in PL lifetime-based oxygen sensitivity by incorporating PtTFPP.
Showcased amplified PL intensity (>12 times) under skin using 980 nm excitation compared to 410 nm.

Conclusions:

The developed nanophotonic sensor enables efficient real-time oxygen detection with enhanced sensitivity.
The 980 nm excitation offers superior performance, particularly for in-vivo applications.
This technology holds promise for developing advanced implantable oxygen sensor platforms.