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Related Concept Videos

Pain01:20

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Related Experiment Video

Updated: Aug 29, 2025

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
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Brain activity changes associated with pain perception variability.

L Crawford1, E Mills1, N Meylakh1

  • 1Department of Anatomy and Histology, School of Medical Sciences, Brain and Mind Centre, University of Sydney, New South Wales 2006, Australia.

Cerebral Cortex (New York, N.Y. : 1991)
|September 7, 2022
PubMed
Summary
This summary is machine-generated.

Pain perception varies between individuals. This study found that variable pain ratings are linked to reduced dorsolateral prefrontal cortex (dlPFC) activity and connectivity, impacting how the brain processes pain signals.

Keywords:
acute painconnectivitydorsolateral prefrontal cortexnoxious stimulipain catastrophizing

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Area of Science:

  • Neuroscience
  • Pain Research
  • Psychology

Background:

  • Pain perception is influenced by various factors, including temporal summation and behavioral conditioning.
  • Individual pain intensity can fluctuate significantly during repeated noxious stimuli, posing challenges for research assuming stable baselines.
  • Understanding pain variability is crucial for accurate studies on analgesic mechanisms and pain modulation.

Purpose of the Study:

  • To investigate neural circuitry differences between individuals with consistent versus variable pain ratings during identical noxious stimuli.
  • To identify brain regions and networks associated with pain variability.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to scan 63 healthy participants.
  • Participants were categorized into 'consistent' (n=31) and 'variable' (n=32) pain rating groups based on their responses to repeated noxious stimuli.
  • Analysis focused on differences in brain signal intensity and functional connectivity between the groups.

Main Results:

  • Variable pain ratings correlated with reduced signal intensity in the dorsolateral prefrontal cortex (dlPFC).
  • The dlPFC showed significantly reduced connectivity with the primary somatosensory cortex and temperoparietal junction in the variable pain group.
  • These neural differences may relate to variations in attentional processing and pain catastrophizing.

Conclusions:

  • Baseline pain variability should be considered in pain research, particularly in studies of pain modulation and analgesic mechanisms.
  • Individuals with consistent and variable pain ratings exhibit distinct dlPFC activity and connectivity patterns.
  • Differences in dlPFC function may underlie variations in attentional control and psychological factors like catastrophizing during pain.