Related Experiment Video

Updated: Aug 29, 2025

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.7K

Diurnal cortisol features with cardiovascular disease in hypertensive patients: a cohort study

Lin Gan1, Nanfang Li1, Mulalibieke Heizati1

  • 1Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute; National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang, China.

European Journal of Endocrinology
|September 7, 2022
PubMed

Insights

Diurnal cortisol patterns, specifically a steep diurnal cortisol slope (DCS), are linked to reduced cardiovascular disease (CVD) risk in hypertensive men. Higher midnight cortisol levels increase CVD risk in this population.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Hypertension Research

Background:

  • The hypothalamic-pituitary-adrenal (HPA) axis and diurnal cortisol patterns are implicated in cardiovascular disease (CVD).
  • The specific impact of diurnal cortisol features on future CVD risk in hypertensive individuals remains unclear.

Purpose of the Study:

  • To investigate the association between diurnal cortisol features and the incidence of CVD.
  • To evaluate the predictive value of cortisol rhythm for CVD events in patients with hypertension.

Main Methods:

  • Utilized data from the Urumqi Research on Sleep Apnea and Hypertension (UROSAH) cohort (2011-2021).
  • Employed Cox proportional hazards models to analyze the relationship between baseline diurnal cortisol features (diurnal cortisol slope and midnight cortisol) and incident CVD.
  • Conducted sex-specific and sensitivity analyses.

Main Results:

  • A steep diurnal cortisol slope (DCS) was associated with a significantly decreased risk of CVD (HR=0.86, P=0.011).
  • Higher midnight cortisol levels were positively associated with an increased risk of CVD (HR=1.24, P=0.002).
  • These associations were primarily observed in men, with no significant link found in the female subgroup.

Conclusions:

  • Flatter DCS and elevated midnight cortisol levels are risk factors for CVD in hypertensive patients, particularly men.
  • Monitoring diurnal cortisol rhythm may aid in identifying hypertensive individuals at higher risk for CVD.
Abstract

More Related Videos

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World10:16

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

Published on: April 7, 2020

8.6K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

835

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
116
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
42
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
57
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
66
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.3K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
790