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Current advances in antibody-based serum biomarker studies: From protein microarray to phage display
Huan Qi1, Jun-Biao Xue1, Dan-Yun Lai1
1Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Proteomics. Clinical Applications
|September 8, 2022
Summary
Technological advances in proteome microarray and phage display enhance antibody-based biomarker discovery. These methods show great potential for identifying biomarkers for clinical applications.
Area of Science:
- Biotechnology
- Immunology
- Proteomics
Background:
- Antibody-based biomarkers are crucial for disease diagnosis and prognosis.
- Proteome microarray and phage display are powerful platforms for antibody profiling.
Purpose of the Study:
- To review technological advancements in antibody-based biomarker studies using proteome microarray and phage display.
- To discuss future development directions in this field.
Main Methods:
- Focus on antibody profiling using proteome microarray and phage display technologies.
- Analysis of technological progress, tools, resources, and platform characteristics.
Main Results:
- Significant improvements in the efficiency of antibody-based biomarker profiling in serum samples.
- Demonstrated capacity and efficiency of proteome microarray and phage display for biomarker identification.
Conclusions:
- Proteome microarray and phage display are effective for biomarker identification.
- Future potential for developing identified biomarkers into clinical applications.
