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Inhibition of Cdk Activity

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Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential.

Saikat Mitra¹, Rajib Das¹, Talha Bin Emran^2,3

¹Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

Frontiers in Pharmacology

|September 8, 2022

Summary

This summary is machine-generated.

Diallyl disulfide (DADS), a compound found in garlic, shows significant potential as an anticancer agent. Research indicates DADS can inhibit tumor growth and spread across various cancer types, offering a promising natural therapeutic avenue.

Keywords:

Pharmacology clinical diallyl disulfide drug discovery garlic oncology pre-clinical

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Area of Science:

Oncology
Natural Products Chemistry
Pharmacology

Background:

Cancer is a leading global cause of mortality, with increasing incidence.
Complementary and alternative therapies for cancer prevention are gaining attention.
Garlic contains diallyl disulfide (DADS), a compound with diverse biological activities.

Purpose of the Study:

To review the anticancer potential of diallyl disulfide (DADS).
To summarize the mechanisms of action, bioavailability, and pharmacokinetics of DADS.
To consolidate findings from clinical and toxicity studies on DADS.

Main Methods:

Literature review of experimental studies on DADS.
Analysis of data on DADS's anti-tumor activity against various cancer cell lines.
Examination of published clinical and toxicity data.

Main Results:

DADS demonstrates anti-tumor activity against a wide range of cancer types, including gynecological, hematological, lung, neural, skin, prostate, gastrointestinal, and liver cancers.
Key anticancer mechanisms of DADS involve inhibiting epithelial-mesenchymal transition (EMT), invasion, and migration.
The review synthesizes information on DADS's efficacy, bioavailability, and pharmacokinetic profile.

Conclusions:

Diallyl disulfide (DADS) presents significant anticancer potential due to its demonstrated efficacy against diverse cancer types.
Understanding DADS's mechanisms of action, bioavailability, and pharmacokinetics is crucial for its therapeutic development.
Further research and clinical studies are warranted to fully explore DADS as a complementary or alternative cancer therapy.