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Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and

Yao Du1, Hui Zhang2, Xiaoyan Nie3

  • 1Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Frontiers in Cardiovascular Medicine
|September 8, 2022
PubMed

Insights

Chronic sterile inflammation drives autoimmune and cardiovascular diseases. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway promotes this inflammation, offering a potential therapeutic target for cardiovascular diseases.

Area of Science:

  • Immunology
  • Cardiovascular Biology
  • Molecular Medicine

Background:

  • Sterile inflammation, characterized by chronic inflammation, is a known driver of autoimmune, metabolic, neurodegenerative, and cardiovascular diseases.
  • Recent research highlights a strong link between inflammatory responses and the development of cardiovascular diseases.

Purpose of the Study:

  • To review the role of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in cardiovascular disease progression.
  • To explore the therapeutic potential of cGAS or STING inhibitors for treating cardiovascular diseases.

Main Methods:

  • This review synthesizes current scientific literature on the cGAS-STING pathway and its involvement in cardiovascular pathology.
  • Analysis of mechanisms by which cytoplasmic DNA activates the cGAS-STING pathway, leading to inflammatory factor and interferon upregulation.

Main Results:

  • The cGAS-STING pathway, activated by cytoplasmic DNA, promotes inflammation via interferon regulatory factor 3 (IRF3) or nuclear factor-κB (NF-κB) activation.
  • This pathway contributes to the progression of various cardiovascular diseases through the upregulation of inflammatory mediators.

Conclusions:

  • The cGAS-STING-mediated inflammatory response plays a significant role in the pathogenesis of cardiovascular diseases.
  • Inhibitors targeting the cGAS-STING pathway represent a promising therapeutic strategy for cardiovascular diseases.

Keywords:
STINGcGAScardiovascular diseasesinflammationtherapy

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